[13] Leyton Orient 0-0 Port Vale [9] 2022-01-22 15:00
Stadium: Matchroom Stadium Round: 28
Referee: Declan Bourne Home Manager: Kenneth Francis Jackett Away Manager: Darrell Clarke
Head to Head
| Anglia - League 2 | 2021/10/02 14:00 | Port Vale v Leyton Orient | L | 3-2 |
| Anglia - League 2 | 2021/02/20 15:00 | Leyton Orient v Port Vale | D | 1-1 |
| Anglia - League 2 | 2020/11/28 13:00 | Port Vale v Leyton Orient | W | 2-3 |
| Anglia - League 2 | 2020/01/18 15:00 | Port Vale v Leyton Orient | L | 1-0 |
| Anglia - League 2 | 2019/09/28 14:00 | Leyton Orient v Port Vale | D | 3-3 |
| Anglia - League 1 | 2015/03/28 15:00 | Leyton Orient v Port Vale | W | 3-1 |
| Anglia - League 1 | 2014/10/25 14:00 | Port Vale v Leyton Orient | L | 3-0 |
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