[13] Leyton Orient 0-0 Port Vale [9] 2022-01-22 15:00
Stadium: Matchroom Stadium Round: 28
Referee: Declan Bourne Home Manager: Kenneth Francis Jackett Away Manager: Darrell Clarke
Head to Head
| Anglia - League 2 | 2021/10/02 14:00 | Port Vale v Leyton Orient | L | 3-2 |
| Anglia - League 2 | 2021/02/20 15:00 | Leyton Orient v Port Vale | D | 1-1 |
| Anglia - League 2 | 2020/11/28 13:00 | Port Vale v Leyton Orient | W | 2-3 |
| Anglia - League 2 | 2020/01/18 15:00 | Port Vale v Leyton Orient | L | 1-0 |
| Anglia - League 2 | 2019/09/28 14:00 | Leyton Orient v Port Vale | D | 3-3 |
| Anglia - League 1 | 2015/03/28 15:00 | Leyton Orient v Port Vale | W | 3-1 |
| Anglia - League 1 | 2014/10/25 14:00 | Port Vale v Leyton Orient | L | 3-0 |
Home History
| Anglia - FA Cup | 2022/01/09 14:00 | Stoke v Leyton Orient | L | 2-0 |
| Anglia - League 2 | 2021/12/18 15:00 | Tranmere v Leyton Orient | L | 1-0 |
| Anglia - League 2 | 2021/12/11 15:00 | Leyton Orient v Crawley Town | L | 1-2 |
| Anglia - League 2 | 2021/12/07 19:45 | Leyton Orient v Swindon | W | 4-1 |
| Anglia - FA Cup | 2021/12/04 15:00 | Leyton Orient v Tranmere | W | 4-0 |
| Anglia - EFL Trophy | 2021/11/30 19:00 | Leyton Orient v Milton Keynes Dons | L | 4-5 |
| Anglia - League 2 | 2021/11/27 15:00 | Northampton v Leyton Orient | L | 1-0 |
| Anglia - League 2 | 2021/11/23 19:45 | Scunthorpe v Leyton Orient | D | 1-1 |
Away History
| Anglia - League 2 | 2022/01/18 19:45 | Port Vale v Salford City | L | 0-1 |
| Anglia - League 2 | 2022/01/15 15:00 | Port Vale v Swindon | L | 1-3 |
| Anglia - FA Cup | 2022/01/08 15:00 | Port Vale v Brentford | L | 1-4 |
| Anglia - League 2 | 2021/12/11 15:00 | Newport County v Port Vale | L | 2-1 |
| Anglia - League 2 | 2021/12/07 19:45 | Bristol Rovers v Port Vale | W | 1-2 |
| Anglia - FA Cup | 2021/12/04 15:00 | Burton Albion v Port Vale | W | 1-2 |
| Anglia - EFL Trophy | 2021/11/30 19:00 | Rotherham v Port Vale | L | 6-4 |
| Anglia - League 2 | 2021/11/27 15:00 | Port Vale v Hartlepool | W | 2-0 |
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