Stadium: James H. Hilton Coliseum
Home Manager: T.J. Otzelberger Away Manager: Donte' Jackson
| NCAAB | 2021/11/16 02:00 | Grambling State v New Mexico | L | 61-86 |
| NCAAB | 2021/11/13 01:00 | Grambling State v Texas Tech | L | 62-88 |
| NCAAB | 2021/11/10 02:00 | Grambling State v Grand Canyon | L | 53-74 |
| NCAAB | 2021/03/13 02:30 | Grambling State v Prairie View | L | 63-74 |
| NCAAB | 2021/03/12 02:30 | Southern v Grambling State | W | 67-72 |
| NCAAB | 2021/03/07 02:00 | Alabama A&M v Grambling State | W | 72-80 |
| NCAAB | 2021/03/05 01:30 | Alabama State v Grambling State | W | 68-91 |
| NCAAB | 2021/03/02 01:30 | Grambling State v Mississippi Valley State | L | 63-67 |
| NCAAB | 2021/11/17 01:00 | Alabama State v Iowa State | W | 60-68 |
| NCAAB | 2021/11/13 01:00 | Oregon State v Iowa State | W | 50-60 |
| NCAAB | 2021/11/10 01:00 | Kennesaw State v Iowa State | W | 73-84 |
| NCAAB | 2021/03/11 02:30 | Iowa State v Oklahoma | L | 73-79 |
| NCAAB | 2021/03/06 22:00 | Iowa State v Kansas State | L | 56-61 |
| NCAAB | 2021/03/05 00:00 | Iowa State v Texas Tech | L | 54-81 |
| NCAAB | 2021/03/03 00:00 | Texas v Iowa State | L | 81-67 |
| NCAAB | 2021/02/27 23:00 | TCU v Iowa State | L | 76-72 |