Stadium: Homer Bryce Stadium Round: 1
Home Manager: Colby Carthel Away Manager: Walt Wells
| NCAAF | 2021/10/30 18:00 | Lamar v Eastern Kentucky | W | 10-42 |
| NCAAF | 2021/10/16 21:00 | Eastern Kentucky v Central Arkansas | W | 38-35 |
| NCAAF | 2021/10/09 22:00 | Abilene Christian v Eastern Kentucky | W | 15-30 |
| NCAAF | 2021/10/02 19:00 | Tarleton State v Eastern Kentucky | W | 3-20 |
| NCAAF | 2021/09/25 19:00 | Austin Peay v Eastern Kentucky | W | 27-35 |
| NCAAF | 2021/09/18 23:00 | Indiana State v Eastern Kentucky | L | 23-21 |
| NCAAF | 2021/09/11 23:00 | Eastern Kentucky v Louisville | L | 3-30 |
| NCAAF | 2021/09/04 22:00 | Eastern Kentucky v Western Carolina | W | 31-28 |
| NCAAF | 2021/10/30 21:00 | Abilene Christian v Stephen F. Austin | W | 27-41 |
| NCAAF | 2021/10/24 01:00 | Stephen F. Austin v Utah Tech | W | 37-20 |
| NCAAF | 2021/10/09 20:00 | Stephen F. Austin v Jacksonville State | L | 24-28 |
| NCAAF | 2021/10/02 21:00 | Sam Houston State v Stephen F. Austin | L | 21-20 |
| NCAAF | 2021/09/25 23:00 | Stephen F. Austin v Lincoln Oaklanders | W | 61-13 |
| NCAAF | 2021/09/18 23:00 | Mississippi Valley State v Stephen F. Austin | W | 13-58 |
| NCAAF | 2021/09/11 23:00 | Stephen F. Austin v Texas Tech | L | 22-28 |
| NCAAF | 2021/09/04 23:00 | Tarleton State v Stephen F. Austin | W | 10-20 |