[5] Northampton 44-26 London Irish [6] 2021-04-16 18:45
Stadium: Franklin's Gardens Round: 16
Referee: Wayne Barnes Home Manager: Chris Boyd Away Manager: Declan Kidney
Head to Head
| Premiership Rugby | 2020/08/22 13:00 | London Irish v Northampton | W | 3-27 |
| Premiership Rugby | 2020/01/24 19:45 | Northampton v London Irish | L | 16-20 |
| Premiership Rugby | 2018/02/17 15:00 | Northampton v London Irish | W | 25-17 |
| Premiership Rugby | 2017/09/24 14:00 | London Irish v Northampton | W | 25-40 |
| Premiership Rugby | 2016/02/13 15:00 | Northampton v London Irish | W | 35-7 |
| Premiership Rugby | 2015/12/26 14:30 | London Irish v Northampton | L | 25-23 |
| Premiership Rugby | 2015/02/13 19:45 | Northampton v London Irish | W | 15-9 |
| Premiership Rugby | 2014/10/04 14:00 | London Irish v Northampton | W | 12-19 |
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