[5] Northampton 44-26 London Irish [6] 2021-04-16 18:45
Stadium: Franklin's Gardens Round: 16
Referee: Wayne Barnes Home Manager: Chris Boyd Away Manager: Declan Kidney
Head to Head
| Premiership Rugby | 2020/08/22 13:00 | London Irish v Northampton | W | 3-27 |
| Premiership Rugby | 2020/01/24 19:45 | Northampton v London Irish | L | 16-20 |
| Premiership Rugby | 2018/02/17 15:00 | Northampton v London Irish | W | 25-17 |
| Premiership Rugby | 2017/09/24 14:00 | London Irish v Northampton | W | 25-40 |
| Premiership Rugby | 2016/02/13 15:00 | Northampton v London Irish | W | 35-7 |
| Premiership Rugby | 2015/12/26 14:30 | London Irish v Northampton | L | 25-23 |
| Premiership Rugby | 2015/02/13 19:45 | Northampton v London Irish | W | 15-9 |
| Premiership Rugby | 2014/10/04 14:00 | London Irish v Northampton | W | 12-19 |
Home History
| European Challenge Cup | 2021/04/10 19:00 | Northampton v Ulster | L | 27-35 |
| European Challenge Cup | 2021/04/03 16:30 | Newport Gwent Dragons v Northampton | W | 39-43 |
| Premiership Rugby | 2021/03/27 15:00 | Worcester Warriors v Northampton | W | 14-62 |
| Premiership Rugby | 2021/03/21 15:00 | Northampton v Bristol | L | 21-28 |
| Premiership Rugby | 2021/03/13 14:45 | Northampton v Sale Sharks | W | 17-14 |
| Premiership Rugby | 2021/03/07 15:00 | Harlequins v Northampton | L | 37-19 |
| Premiership Rugby | 2021/02/28 13:00 | Northampton v Bath | L | 22-23 |
| Premiership Rugby | 2021/02/20 15:00 | Exeter Chiefs v Northampton | W | 12-13 |
Away History
| European Challenge Cup | 2021/04/09 19:00 | Bath v London Irish | L | 26-13 |
| European Challenge Cup | 2021/04/02 16:30 | London Irish v Cardiff Blues | W | 41-35 |
| Premiership Rugby | 2021/03/27 15:00 | London Irish v Bath | W | 36-33 |
| Premiership Rugby | 2021/03/21 15:00 | Sale Sharks v London Irish | L | 41-13 |
| Premiership Rugby | 2021/03/14 13:00 | London Irish v Worcester Warriors | W | 20-17 |
| Premiership Rugby | 2021/03/05 19:45 | Leicester v London Irish | L | 33-32 |
| Premiership Rugby | 2021/02/27 15:00 | Wasps v London Irish | W | 10-16 |
| Premiership Rugby | 2021/02/21 15:00 | London Irish v Bristol | D | 34-34 |
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