| French Open - Feminin | 05/21 11:25 | 14 | [235] Despina Papamichail v Daria Snigur [123] | 5-7,2-6 | |
| ITF - W100 Madrid | 05/15 08:50 | 25 | [221] Xiaodi You v Despina Papamichail [231] | 7-6,6-2 | |
| ITF - W100 Madrid | 05/13 10:35 | 54 | [231] Despina Papamichail v Martyna Kubka [351] | 7-6,6-3 | |
| ITF - W100 Madrid | 05/12 11:45 | 54 | Despina Papamichail v Paula Arias Manjon | 6-2,6-7,6-2 | |
| ITF - W75 Praga | 05/08 08:50 | 25 | [305] Jaimee Fourlis v Despina Papamichail [231] | 6-4,7-6 | |
| WTA - Lleida | 05/01 08:00 | 25 | [237] Despina Papamichail v Magdalena Frech [51] | 2-6,4-6 | |
| WTA - Lleida | 04/30 10:25 | 14 | [237] Despina Papamichail v Yvonne Cavalle-Reimers [293] | 6-4,6-0 | |
| ITF - W75 Chiasso | 04/17 12:30 | 25 | [235] Despina Papamichail v Maria Sara Popa [432] | 7-5,5-7,6-7 | |
| Billie Jean King Cup | 04/09 10:00 | 1 | [111] Aleksandra Krunic v Despina Papamichail [235] | 6-0,6-3 | |
| Billie Jean King Cup | 04/08 09:50 | 1 | [469] Kajsa Rinaldo Persson v Despina Papamichail [235] | 4-6,4-6 | |
| ITF - W35 Santa Margherita | 04/03 07:25 | 25 | [245] Despina Papamichail v Diletta Cherubini [412] | 2-6,7-6,4-6 | |
| ITF - W35 Terrassa | 03/29 09:30 | 28 | [260] Despina Papamichail v Lois Boisson [293] | 3-6,6-0,1-6 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 93, achieved on 4 December 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 37 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 31–29 (as of May 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event by defeating Gabriela Cé, her first title above $25k level.
She made her WTA Tour main-draw debut 2021 at the WTA 500 event in Abu Dhabi.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
Later, she qualified for the Pan Pacific Open and defeated lucky loser Sakura Hosogi.